Let’s be trustworthy, getting older sucks typically. You get up feeling such as you want three cups of espresso simply to really feel half as energetic as you probably did in your twenties. Sound acquainted?
Properly, right here’s the factor: there’s this molecule referred to as NAD+ (nicotinamide adenine dinucleotide, in the event you’re into the science-y stuff) that mainly acts like your physique’s mobile battery charger. And guess what? It begins draining quicker than your cellphone battery after age 30.
The excellent news? Scientists have been geeking out over NAD+ dietary supplements currently, and for good cause. These little capsules would possibly simply be the closest factor we’ve acquired to a fountain of youth, minus the legendary spring water and plus some precise analysis.
7 Finest NAD+ Dietary supplements in 2025
Right here’s my breakdown of the highest NAD+ boosters in the marketplace proper now:
What Can NAD+ Dietary supplements Truly Do for You?
Earlier than we dive into the most effective dietary supplements, let’s speak advantages. And no, I’m not going to vow you’ll immediately look 25 once more (sorry). However analysis is exhibiting some fairly spectacular potential:
Now, let me be clear: NAD+ dietary supplements aren’t magic capsules. However the science is getting extra thrilling by the day, with medical trials exhibiting they’re usually protected and may successfully increase NAD+ ranges in people. Even longevity consultants like Dr. David Sinclair swear by them.
1. Finest Total: Renue By Science Complete NAD+ Restoration Protocol
Okay, so think about if somebody took all the most effective NAD+ analysis and crammed it into one complete protocol. That’s mainly what Renue did right here. (And hey, it can save you 10% on any Renue merchandise with code BRAINFLOW!)
This isn’t simply one other tablet you pop and neglect. The Complete NAD+ Restoration Protocol is just like the Swiss Military knife of anti-aging dietary supplements. You get morning capsules, night capsules, and every thing in between, all designed to deal with NAD+ decline from a number of angles. For a deeper dive into Renue’s merchandise, take a look at our detailed NMN evaluation.
What makes it particular: The protocol consists of 14 totally different elements working collectively. You’ve acquired your NAD+ precursors (NMN and NR), but in addition CD38 inhibitors (these cease the enzyme that eats up your NAD+ as you age), senolytics to filter zombie cells, and particular formulation for day and evening help.
The liposomal supply is clutch right here as a result of it protects the elements out of your abdomen acid so they really make it to your cells. Common dietary supplements would possibly offer you 5-10% absorption, however liposomal? We’re speaking 90%+.
The morning formulation provides you power with out the jitters, whereas the nighttime mix helps you sleep higher and helps mobile restore when you snooze. It’s like having a 24/7 anti-aging crew working for you.
Actual speak: Customers report feeling extra energetic inside a pair weeks, higher exercise restoration, and sharper psychological readability. One reviewer talked about feeling like they “aged backwards” after two months. The bundle really saves you about 50 bucks in comparison with shopping for every thing individually, which is sweet.
The downsides: You’ll have to be organized since this isn’t a one-pill scenario. And yeah, it’s expensive. However in the event you’re severe about complete NAD+ help, that is nearly as good because it will get.
Get it: Store on Renue By Science with code BRAINFLOW for 10% off
2. Runner-Up: Wonderfeel Youngr™ NMN
Generally you simply need one actually good complement as a substitute of a complete protocol. Enter Wonderfeel Youngr.
This unhealthy boy packs 900mg of NMN per serving, which is just like the Lamborghini of NMN doses. However they didn’t cease there. The formulation consists of trans-resveratrol (the stuff that makes pink wine “wholesome”), olive fruit extract, ergothioneine from mushrooms, and vitamin D3. This dosing aligns with what Andrew Huberman discusses in his NMN protocol.
Why I dig it: The Harvard MD who formulated this clearly did their homework. Every ingredient has a selected job. NMN boosts NAD+, resveratrol prompts your longevity genes, ergothioneine is that this loopy antioxidant that goes wherever your physique wants it most, and the olive extract helps your coronary heart and mind.
You’ll be able to take one capsule (450mg) to stretch your provide or go full throttle with two capsules. Even at half dose, you’re getting extra NMN than most opponents provide at full dose.
What customers say: Individuals report higher power, improved focus, and a few even point out higher sleep (which appears counterintuitive for an power complement, however is smart when your cells are functioning higher). The resveratrol-NMN combo is especially good as a result of it’s like giving your longevity genes each the gasoline and the ignition change.
The catch: At round $88 per bottle, it’s not low-cost. And the capsules aren’t enteric-coated, so a tiny little bit of NMN would possibly break down in abdomen acid. However actually? For a single-supplement resolution, that is robust to beat.
Get it: Store Wonderfeel Youngr immediately
3. Finest Finances Decide: Renue By Science Lipo NAD+ Full
Who says you must break the financial institution for high quality NAD+ help? This liposomal formulation from Renue is proof that budget-friendly doesn’t imply reducing corners. Plus, with code BRAINFLOW, you’ll save an additional 10% on high of the already nice value!
Right here’s the kicker: this complement incorporates precise NAD+ (not simply precursors), plus NMN, NR, and trigonelline. It’s like getting 4 dietary supplements in a single capsule. Most firms keep away from placing NAD+ immediately in dietary supplements as a result of it normally will get destroyed in your intestine, however Renue’s liposomal know-how protects it.
The science bit: Every ingredient takes a barely totally different path to spice up your NAD+. Having a number of precursors means your physique can use whichever pathway is working greatest at any given time. The trigonelline (a particular type of B3) helps help power metabolism and has been proven to cut back fatigue.
At round $50-60 for a two-month provide, we’re speaking lower than a greenback a day. Examine that to Tru Niagen at $90 for one month, and also you see why that is our finances champion.
High quality test: Made within the USA, third-party examined, vegan-friendly, and no bizarre fillers. Renue posts all their check outcomes on-line, which I admire. Transparency for the win.
Minor gripes: Since every capsule splits the dose between 4 elements, hardcore biohackers would possibly need to take two capsules every day. And it sells out often (in all probability as a result of it’s such a great deal).
Get it: Obtainable on Renue’s web site (use code BRAINFLOW for 10% off)
4. Finest Powder Possibility: Renue By Science PURE NMN Powder
Generally you need most management over your dosing, or perhaps you simply hate swallowing capsules. Both approach, Renue’s NMN powder has you coated.
That is pharmaceutical-grade NMN with over 99% purity, mainly as clear because it will get. At about $1.50 per gram when purchased in bulk, you’re saving severe money in comparison with capsules. Tru Niagen prices over $5 per gram, so do the maths. Don’t neglect to make use of code BRAINFLOW for an additional 10% off!
Learn how to use it: Combine it in water, juice, or let it dissolve beneath your tongue (sublingual crew, the place you at?). The sublingual methodology would possibly offer you quicker outcomes because it bypasses digestion. Begin with 250-500mg every day, although some biohackers go as much as 1 gram or extra.
Professional tip: The style is barely bitter however not horrible, form of like unsweetened inexperienced tea. Retailer it correctly (cool, dry, hermetic) and it’ll final for months. Simply don’t combine it with scorching drinks as a result of warmth can degrade NMN.
One factor to contemplate: in the event you’re taking excessive doses long-term, add some TMG (trimethylglycine) or a B-complex to help methylation. Excessive-dose NMN can burn up your methyl teams, and also you need to hold that cycle balanced.
Regardless of these minor duties, the worth right here is unbeatable. For anybody on a long life journey seeking to experiment with dosages, Renue’s NMN powder is the most effective NAD complement in bulk kind. It has hundreds of happy clients and a stable status within the biohacking group (Renue was previously often called Alive By Science, a trusted pioneer in NAD analysis). Given its purity, high quality, and cost-effectiveness, this powder is the way in which to go for NAD boosting on a finances.
Good for: DIY biohackers, anybody who needs to experiment with dosing, or of us on the lookout for the very best worth per gram.
Get it: Store immediately from Renue By Science and save 10% with code BRAINFLOW
5. Finest NR Possibility: Tru Niagen®
The OG of NAD+ dietary supplements deserves respect. Tru Niagen put nicotinamide riboside (NR) on the map, they usually’ve acquired the analysis to again it up.
ChromaDex (the corporate behind Tru Niagen) holds the patent on Niagen® NR and has funded tons of research. Their analysis reveals NR can increase NAD+ by about 40-60% in wholesome adults. Not too shabby.
Why NR over NMN? It’s acquired an extended monitor document in human research and FDA GRAS standing (Usually Acknowledged As Protected). Plus, as of 2023, the FDA began questioning NMN’s complement standing, whereas NR remains to be freely bought. Politics, am I proper?
Every capsule has 300mg of NR chloride. One every day is the usual dose, although some folks double up. At about $90 for 90 capsules, it’s pricier than NMN per milligram, however you’re paying for that in depth analysis and high quality management.
What to anticipate: Customers report refined however actual enhancements like higher power, improved endurance, much less fatigue. Some point out higher pores and skin and sleep too. It’s not an power drink jolt; it’s extra like your cells slowly recharging over 2-4 weeks.
The NSF Licensed for Sport certification is large in the event you’re an athlete since each batch is examined for banned substances. Scientific research have additionally proven potential advantages for blood stress and muscle metabolism.
Backside line: If you would like essentially the most researched, regulatory-approved NAD+ booster with zero sketchy elements, Tru Niagen is your jam.
Get it: Store at TruNiagen.com, Amazon, or discover it in shops
6. Finest Quick-Performing: Quicksilver Scientific NAD+ Gold
Want outcomes yesterday? NAD+ Gold is your reply.
This liquid liposomal formulation is designed for velocity. You pump it in your mouth, maintain for 30 seconds, and the tiny nanoparticles begin absorbing via your oral tissues. No ready for digestion. It’s just like the categorical lane for NAD+ boosting.
Every pump provides you 50mg NMN plus 50mg TMG (for methylation help). The dose appears small, however the liposomal supply makes it punch approach above its weight. Plus, analysis reveals NMN might be transported immediately into cells for fast NAD+ manufacturing.
TMG is clutch right here: NAD+ manufacturing makes use of up methyl teams, and TMG donates them again. It’s like having a delegated driver on your mobile processes that retains every thing balanced whereas NMN does its factor.
Customers love this for pre-workout power or morning mind fog. The results hit quick, we’re speaking 15-Half-hour as a substitute of hours. Some folks take 2-4 pumps for a stronger impact, however begin with one and see how you are feeling.
The truth test: At round $45 for a 30ml bottle, the fee per gram of NMN is astronomical (over $25/gram by some calculations). You’re paying for that nano-delivery know-how. Additionally, it wants refrigeration after opening and tastes… medicinal.
However if you wish to really feel NAD+ advantages ASAP, nothing else comes shut.
Get it: Quicksilver Scientific direct or licensed retailers
7. Finest with Added Synergists: Cymbiotika NMN + Trans-Resveratrol
Final however undoubtedly not least, Cymbiotika’s formulation is what occurs once you mix NAD+ boosting with severe antioxidant firepower.
Every serving packs 400mg NMN, 100mg trans-resveratrol, and right here’s the game-changer: 200mg apigenin. Most individuals haven’t heard of apigenin, but it surely’s this flavonoid from chamomile that inhibits CD38, the enzyme that breaks down NAD+ as we age.
Give it some thought. Most dietary supplements simply increase NAD+. This one boosts it AND protects it from being destroyed. It’s like filling your fuel tank whereas additionally fixing the leak.
The synergy is actual: Resveratrol prompts sirtuins (your longevity genes), NMN supplies the gasoline for these genes, and apigenin makes positive that gasoline doesn’t get wasted. Dr. David Sinclair, the Harvard longevity researcher, takes an analogous combo.
Customers report higher exercises, quicker restoration, and enhancements in pores and skin and hair well being. The anti-inflammatory results from apigenin and resveratrol would possibly clarify why folks really feel so good on this.
Value level: At $77 per bottle, it’s up there. However take into account you’re primarily getting three premium dietary supplements in a single. If you happen to purchased NMN, resveratrol, and an apigenin individually, you’d spend far more.
The one warning: some individuals are delicate to resveratrol, so take it with meals. And it’s solely out there via Cymbiotika or choose retailers, no Amazon right here.
Get it: Store Cymbiotika immediately or discover it at licensed retailers
The Backside Line
Look, I’m not saying NAD+ dietary supplements will flip you right into a superhuman in a single day. However the science is legit, and these seven merchandise signify the most effective of what’s on the market in 2025.
Whether or not you go all-in with Renue’s complete protocol or hold it easy with Tru Niagen, you’re giving your cells some severe help. Simply keep in mind that dietary supplements work greatest when paired with the fundamentals: good sleep, common train, and never residing on pizza alone (belief me, I’ve tried).
Begin with the beneficial dose, give it no less than 4-6 weeks, and see how you are feeling. And hey, perhaps test along with your physician first, particularly in the event you’re on drugs or have well being circumstances. Most research present NAD+ boosters are protected as much as about 1000mg every day, however everybody’s totally different.
Right here’s to feeling youthful, considering sharper, and having the power to really take pleasure in life. As a result of what’s the purpose of residing longer in the event you don’t really feel good doing it? If you happen to loved this text, take a look at our full information to the most effective NMN dietary supplements.
Sources: The analysis backing these dietary supplements retains rising. Take a look at research from Medical Information At the moment, Well being.com, and up to date medical trials for the newest. Science is cool, of us!
