Key takeaways:
- Free testosterone rose from 4.8 ng/dL earlier than bariatric surgical procedure to eight.4 ng/dL at 3 years.
- Change in testosterone after surgical procedure was not related to change in fats mass or fat-free mass.
SAN FRANCISCO — Male adolescents who underwent bariatric surgical procedure had a rise in free testosterone after surgical procedure that was not tied to a discount in fat-free mass, in line with knowledge offered at ENDO 2025.
Utilizing knowledge from the Teen-LABS research, Sandeep Dhindsa, MD, professor of medication and chief of the division of endocrinology and metabolism at Saint Louis College, mentioned researchers assessed whether or not will increase in free testosterone following bariatric surgical procedure may assist shield towards lean mass loss.
“When folks reduce weight, they’re additionally shedding lean mass, and [patients are] a bit involved about that, they simply wish to lose fats and don’t wish to lose lean mass.” Dhindsa informed Healio. “However [lean mass loss] occurs in each sort of weight reduction. The query was that if the testosterone ranges are going up, will this in some way assist to protect lean mass?”
Sandeep Dhindsa
The research included 34 adolescents aged 19 years and youthful who underwent bariatric surgical procedure from 2007 to 2012. Physique composition was assessed earlier than the process, at 6 months after which yearly as much as 5 years after surgical procedure. Whole testosterone, intercourse hormone-binding globulin, IGF-I and free testosterone have been collected.
The research group had a imply BMI of 53.1 kg/m2, imply fats mass of 90.5 kg and fat-free mass of 74.1 kg at baseline.
In line with the summary, imply free testosterone ranges elevated from 4.8 ng/dL earlier than bariatric surgical procedure to 7.7 ng/dL at 6 months after surgical procedure, 8 ng/dL at 1 yr, 8.4 ng/dL at 3 years and seven.8 ng/dL at 5 years (P < .001 for all). Imply IGF-I ranges elevated from 68 ng/mL at baseline to 81 ng/mL at 6 months (P = .02). There was no important change in IGF-I after 6 months.
Free testosterone was positively correlated with fat-free mass (r = 0.37; P = .05) and negatively correlated with fats mass (r = –0.44; P = .02) earlier than surgical procedure. IGF-I used to be positively correlated with fats mass (r = 0.52; P = .02), however not fat-free mass at baseline.
In line with the summary, fats mass decreased by a imply 49 kg at 6 months and 60 kg at 1 yr after surgical procedure in contrast with baseline. Fats mass elevated after 1 yr, however remained 46 kg decrease than baseline at 5 years after surgical procedure (P < .001).
Change in free testosterone and IGF-I used to be not related to change in fats mass or fat-free mass after surgical procedure.
“Testosterone will rise after weight reduction,” Dhindsa mentioned. “But when they have been hoping that the rise in testosterone would in some way assist them not lose the lean mass, that is not going to occur.”
Dhindsa mentioned well being care professionals treating weight problems ought to be conscious that change in fat-free mass following bariatric surgical procedure will happen extra slowly than the rise in testosterone.
“It offers you one bit of data which you’ll be able to then make the most of to determine … if I am so apprehensive about preserving lean mass proper after bariatric surgical procedure, I might have to offer the affected person testosterone substitute,” Dhindsa mentioned.
For extra info:
Sandeep Dhindsa, MD, will be reached at sandeep.dhindsa@well being.slu.edu.
Sources/Disclosures
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Dhindsa S, et al. Summary OR22-04. Offered at: ENDO annual assembly; July 12-15, 2025; San Francisco.
Disclosures:
The authors report no related monetary disclosures.
