Key takeaways:
- Amongst sufferers with osteoporosis who had a fracture at age 80 or older, these on pharmacological therapy had been much less prone to die or be hospitalized at 5 years.
- A potential research on the subject could come.
SAN FRANCISCO — Initiating pharmacological therapy in sufferers aged no less than 80 years who’ve had a fracture seems to be useful, researchers reported at ENDO 2025.
Gianina Flocco, MD, a resident at Cleveland Clinic, and colleagues carried out an observational research utilizing the TriNetX well being analysis database of sufferers with osteoporosis identified with a fracture at age 80 years or older. They in contrast 54,498 sufferers who obtained pharmacological therapy akin to bisphosphonates, denosumab (Prolia, Amgen), raloxifene or teriparatide with 78,448 sufferers who didn’t obtain any pharmacological therapy for osteoporosis after a fracture, forming 44,338 pairs matched by way of propensity rating.
Older adults with osteoporosis had a decrease danger for hospitalizations and mortality in the event that they obtained pharmacotherapy following a fracture. Picture: Adobe Inventory
“Because the getting older of the worldwide inhabitants accelerates, the burden of osteoporosis is rising, and aged People are anticipated to expertise a threefold enhance in osteoporotic fractures. Superior age is related to decrease use of pharmacological therapy to forestall fractures on account of considerations about comorbidities and prognosis. The variety of sufferers over 80 who obtain pharmacological therapy for osteoporosis apart from dietary supplements may be very low. There’s debate on the influence of initiation of pharmacological therapy for osteoporosis within the oldest outdated. The purpose of this research was to check outcomes of sufferers with osteoporosis who had been on pharmacological therapy for osteoporosis after experiencing a fracture at age 80 or older vs. sufferers who suffered a fracture on the similar age however didn’t obtain pharmacological therapy.”
The outcomes of curiosity had been hospitalization and demise at 5 years.
At 5 years, amongst individuals within the matched pairs, the pharmacological group had fewer hospitalizations in contrast with the nonpharmacological group (18,142 sufferers vs. 20,385 sufferers; OR = 0.81; 95% CI, 0.79-0.84), Flocco stated in the course of the presentation.
As well as, fewer sufferers from the pharmacological group died inside 5 years in contrast with the nonpharmacological group (11,073 sufferers vs. 12,479 sufferers; OR = 0.85; 95% CI, 0.83-0.88), she stated.
“Sufferers with osteoporosis who had been began on pharmacological therapy after experiencing a fracture at age 80 or older could expertise fewer hospitalizations and have decrease all-cause mortality in comparison with those that didn’t,” Flocco stated in the course of the presentation.
Provided that retrospective research have confounders, researchers at Cleveland Clinic are designing a potential research on this subject, which may make clear why some sufferers from this inhabitants aren’t prescribed pharmacological remedy for osteoporosis, Flocco stated.
Sources/Disclosures
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Flocco G, et al. OR10: Bone and mineral metabolism: Advances in scientific bone administration. Introduced at: ENDO annual assembly; July 12-15, 2025; San Francisco.
Disclosures:
The authors report no related monetary disclosures.
