Key takeaways:
- Researchers noticed considerably worse OS amongst sufferers who primarily consumed a proinflammatory food regimen.
- Each food regimen and bodily exercise influenced OS.
CHICAGO — Consuming a noninflammatory food regimen elevated OS for sufferers with late-stage colon most cancers, in keeping with findings from a big, potential cohort research introduced at ASCO Annual Assembly.
Of observe, common bodily exercise appeared to attenuate the affiliation between food regimen and OS. Researchers subsequently advocate extra analysis on a food regimen and bodily exercise intervention.
Knowledge derived from Char SK, et al. Summary LBA3509. Offered at: ASCO Annual Assembly; Might 30-June 3, 2024; Chicago.
Measuring irritation
“We all know that systemic irritation within the physique is implicated in each colon most cancers improvement and in its development, and that elevated ranges of inflammatory markers within the blood have beforehand been related to worse survival outcomes in sufferers with stage III colon most cancers,” Sara Okay. Char, MD, researcher within the division of medical oncology at Dana-Farber Most cancers Institute, stated throughout a press briefing. “Moreover, information introduced earlier this yr confirmed that low-dose every day aspirin, which is an anti-inflammatory treatment, can scale back the recurrence fee in stage II to stage III colon most cancers with PI3-kinase pathway alterations.”
Sara Okay. Char
For these causes, Char and colleagues got down to assess the consequences of a extra inflammatory food regimen vs. a much less inflammatory food regimen on the chance for colon most cancers recurrence amongst a subset of 1,625 sufferers included within the section 3 CALGB/SWOG 80702 medical trial, which analyzed 3 months vs. 6 months of adjuvant chemotherapy, with or with out celecoxib.
Sufferers (median age, 60.9 years) included within the potential cohort research had surgically resected stage III colon most cancers.
Researchers used the empirical dietary inflammatory sample (EDIP) software — a weighted sum of 18 meals teams, together with 9 proinflammatory and 9 anti-inflammatory — to attain affected person diets. Excessive EDIP scores corresponded to a extra proinflammatory food regimen vs. a low EDIP rating, which represented a much less inflammatory food regimen.
Proinflammatory meals included crimson meat, processed meats, refined grains and sugary drinks, and anti inflammatory meals included espresso, tea, darkish yellow greens and leafy inexperienced greens.
“The EDIP software permits us to measure the inflammatory potential of a food regimen, and has been validated beforehand in a number of massive cohorts,” Char stated. “The rating that one will get from this dietary sample can statistically correlate the consumption of particular meals with plasma ranges of the inflammatory markers.”
Researchers moreover distributed meals frequency questionnaires at two time factors, throughout which sufferers answered questions on 131 meals they consumed through the earlier 3 months.
Main consequence was DFS; secondary consequence was OS.
Prescribe nutritious diet, train
Total, in contrast with sufferers within the highest EDIP quintile, these within the lowest quintile have been youthful (61.3 years vs. 58.7 years), extra prone to be ladies (48.9% vs. 64%) and expertise worse efficiency standing (ECOG standing 1-2: 19.4% vs. 35.7%). Sufferers within the highest EDIP quintile have been extra prone to be Black (15.4% vs. 3.7%).
At median follow-up of three.96 years, outcomes of a multivariable adjusted mannequin confirmed no vital distinction in DFS between sufferers who primarily consumed a proinflammatory vs. anti-inflammatory food regimen (HR = 1.36; 95% CI, 0.99-1.86).
Nonetheless, researchers noticed considerably worse OS amongst sufferers who primarily consumed a proinflammatory vs. anti-inflammatory food regimen (multivariable HR = 1.87; 95% CI, 1.26-2.77).
Char famous that each food regimen and bodily exercise influenced OS.
“We wished to look at the joint impact of bodily exercise and food regimen on OS, as we all know that each can impression systemic irritation,” she stated. “For bodily exercise, we divided our cohort into greater and decrease ranges of bodily exercise utilizing a cutoff of 9 MET hours per week, which roughly correlates to half-hour of vigorous strolling 5 days per week with gentle yoga.”
Among the many 4 teams of upper and decrease bodily exercise and proinflammatory food regimen, Char added that, “sufferers with higher survival outcomes have been those that engaged in greater ranges of bodily exercise and consumed much less inflammatory diets in contrast with these with decrease bodily exercise and who consumed extra inflammatory diets, with an HR for OS of 0.37.
“Normally, [EDIP] is a great tool to measure the inflammatory potential of a food regimen, however shouldn’t be a dietary suggestion,” she stated. “We want additional research to have the ability to tailor our findings into dietary suggestions that may be supplied to sufferers on the bedside.”
Julie R. Gralow, MD, FACP, FASCO, chief medical officer and government vp of ASCO, applauded the research.
Julie R. Gralow
“We as physicians must prescribe nutritious diet and train, as the mixture of the 2 are synergistic. As we’re engaged on how you can make our medical trials extra environment friendly and ‘get extra out of much less,’ this was embedded in an ongoing research wanting on the variety of cycles of chemotherapy and whether or not celecoxib may impression survival [in these patients]. So we are able to squeeze quite a bit out of our federally funded analysis if we plan it proper. One other vital level right here, particularly primarily based on how a lot I’ve had this morning, is that espresso falls within the low-inflammatory food regimen class.”
For extra data:
Sara Okay. Char, MD, will be reached at hematologyoncology@healio.com.
Sources/Disclosures
Collapse
Char SK, et al. Summary LBA3509. Offered at: ASCO Annual Assembly; Might 30-June 3, 2024; Chicago.
Disclosures:
Char studies no related monetary disclosures. Please see the research for all different authors’ related monetary disclosures. Gralow studies no related monetary disclosures.
