For adults with kind 2 diabetes and weight problems, glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are related to a decrease danger for dementia, stroke, and all-cause mortality in contrast with different antidiabetic medicine, based on a research revealed on-line July 15 in JAMA Community Open.
Huan-Tang Lin, M.D., Ph.D., from Chang Gung Memorial Hospital at Linkou in Taiwan, and colleagues examined the affiliation of semaglutide and tirzepatide with the incidence of dementia, Parkinson illness, ischemic stroke, intracerebral hemorrhage, and all-cause mortality in comparison with different antidiabetic medicine in a retrospective cohort research analyzing digital well being record-based information for adults aged 40 years or older with kind 2 diabetes and weight problems.
The research included 60,860 adults with kind 2 diabetes and weight problems: 30,430 within the GLP-1 RA group and 30,430 within the different antidiabetic drug group (biguanides, sulfonylureas, dipeptidyl peptidase 4 inhibitors, sodium-glucose cotransporter 2 inhibitors, thiazolidinediones, and α-glucosidase inhibitors) after propensity rating matching.
The researchers discovered that GLP-1 RA customers had a decrease danger for dementia, ischemic stroke, and all-cause mortality throughout a seven-year follow-up (hazard ratios, 0.63, 0.81, and 0.70, respectively), whereas no important variations have been seen within the dangers for Parkinson illness or intracerebral hemorrhage. Larger advantages have been seen for these aged 60 years or older, ladies, and sufferers with a physique mass index of 30 to 40 kg/m2.
“These findings spotlight the doable function of GLP-1 RAs in mitigating neurodegenerative and cerebrovascular dangers on this high-risk inhabitants,” the authors write.
Extra info:
Huan-Tang Lin et al, Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Sufferers With Diabetes and Weight problems, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.21016
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Threat for dementia, ischemic stroke, mortality decrease with GLP-1 receptor agonists in kind 2 diabetes, weight problems (2025, July 22)
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