Key takeaways:
- Ladies with weight problems taking tirzepatide had enhancements in ASCVD threat rating; males didn’t.
- Cardiometabolic parameters improved for each men and women after 12 months of tirzepatide.
SAN FRANCISCO — In sufferers with weight problems, tirzepatide improved cardiometabolic parameters and threat for heart problems, however the modifications have been extra pronounced in girls, researchers reported at ENDO 2025.
“We undertook this research to research how tirzepatide, a twin GLP-1/GIP receptor agonist and the simplest weight problems treatment at the moment accessible, influences cardiovascular and metabolic well being in a real-world inhabitants, notably given the restricted information on its cardiovascular outcomes and sex-specific results,” Regina Castaneda Hernandez, MD, a analysis fellow within the division of ladies’s well being at Mayo Clinic, and Maria Daniela Hurtado Andrade, MD, PhD, an assistant professor of drugs within the division of endocrinology, diabetes and metabolism at Mayo Clinic, instructed Healio. “Weight problems is a serious modifiable threat issue for heart problems, and GLP-1 receptor agonists have already demonstrated advantages in decreasing cardiovascular occasions. Nevertheless, sex-specific variations in therapy response are sometimes missed in scientific trials. Recognizing that men and women might expertise totally different metabolic trajectories and responses to remedy, our objective was to evaluate how tirzepatide impacts atherosclerotic heart problems (ASCVD) threat and associated cardiometabolic parameters in each sexes. This sex-informed method helps handle the longstanding underrepresentation of ladies in cardiovascular and metabolic analysis.”
The researchers analyzed 831 sufferers with weight problems taking tirzepatide (Zepbound, Eli Lilly) for weight reduction (imply age, 57.5 years; 59.4% girls; 91% white; imply BMI, 33.7 kg/m2). The outcomes of curiosity have been whole physique weight reduction eventually follow-up (18 months), modifications in cardiometabolic parameters at 12 months and modifications in ASCVD threat rating at 12 months, all stratified by intercourse.
Finally follow-up, girls misplaced a larger proportion of whole physique weight than males (–14.8 vs. –10.4; distinction, 8.6 proportion factors; 95% CI, 8.5-8.8; P = .01), in accordance with the researchers.
At 12 months, men and women had related enhancements in fasting glucose, HbA1c, whole ldl cholesterol, LDL ldl cholesterol, HDL ldl cholesterol and trigylcerides, however girls improved greater than males in blood strain, notably diastolic blood strain (distinction, 3.1 mm Hg; P = .02), the researchers discovered.
Amongst 393 members who had an ASCVD threat rating calculated, at 12 months, the 10-year ASCVD threat rating improved extra in girls than in males (–16% vs. +2%; P < .01), in accordance with the researchers.
“We noticed a discount in 10-year ASCVD threat amongst girls, however not in males,” Castaneda Hernandez and Hurtado Andrade instructed Healio. “Nevertheless, when contemplating the pure, age-related improve in ASCVD threat over time, each sexes demonstrated enchancment, indicating that tirzepatide might assist mitigate the anticipated rise in cardiovascular threat related to ageing. This impact is probably going mediated by tirzepatide’s broad metabolic advantages, together with substantial weight reduction, improved glycemic management, reductions in systolic blood strain and favorable modifications in lipid profiles (ie, decrease ranges of triglycerides, LDL ldl cholesterol and whole ldl cholesterol, together with elevated HDL ldl cholesterol). The extra pronounced enchancment noticed in girls might replicate larger reductions in whole physique weight and extra favorable lipid responses.
“General, these findings help the speculation that focusing on central adiposity and enhancing metabolic well being can attenuate the development of ASCVD threat, notably in girls. Recognizing that girls might derive larger cardiometabolic profit from tirzepatide may inform threat stratification and information therapeutic selections. As customized medication advances, integrating intercourse as a organic variable can be important in optimizing outcomes.”
The findings function a reminder that intercourse variations might have scientific implications, the researchers stated.
“This research provides to the rising physique of proof that intercourse variations can meaningfully affect therapeutic response, even in metabolic and cardiovascular domains,” Castaneda Hernandez and Hurtado Andrade instructed Healio. “Traditionally, girls have been underrepresented in cardiovascular analysis, limiting our understanding of sex-specific therapy results. Our findings spotlight the significance of together with sex-stratified analyses in scientific analysis and underscore the worth of tailoring therapy approaches primarily based not solely on scientific parameters but additionally on organic intercourse.”
For extra data:
Regina Castaneda Hernandez, MD, could be reached at castaneda.regina@mayo.edu.
Maria Daniela Hurtado Andrade, MD, PhD, could be reached at hurtado.mariadaniela@mayo.edu.
Sources/Disclosures
Collapse
Castaneda R, et al. Summary RF35-03. Introduced at: ENDO annual assembly; July 12-15, 2025; San Francisco.
Disclosures:
Hurtado Andrade reviews receiving advisory charges from Novo Nordisk and Phenomix Sciences. Castaneda Hernandez reviews no related monetary disclosures.
