Anti-obesity medicines can considerably elevate testosterone ranges and enhance well being outcomes for males with weight problems or sort 2 diabetes, in response to a brand new research being offered Monday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
Testosterone not solely performs a crucial position within the physique in terms of male sexual functioning, however it will possibly additionally have an effect on a person’s bone mass, fats distribution, muscle mass, power and crimson blood cell manufacturing. Will increase in physique weight and prevalence of sort 2 diabetes are sometimes related to lowered testosterone ranges, leading to fatigue, decreased libido and high quality of life.
“Whereas it’s well-known that weight reduction from way of life modifications or bariatric surgical procedure will increase testosterone ranges, the influence that anti-obesity medicines may have on these ranges has not been extensively studied,” stated Shellsea Portillo Canales, M.D., endocrinology fellow at SSM Well being St. Louis College Hospital in St. Louis, Mo. “Our research is among the many first to offer compelling proof that low testosterone could be reversed with using generally prescribed anti-obesity medicines.”
To check this speculation, researchers analyzed the digital well being data of 110 grownup males with weight problems or sort 2 diabetes being handled with the weight-loss medicines semaglutide, dulaglutide or tirzepatide and who weren’t on testosterone or hormonal remedy. Members’ complete and free testosterone ranges have been measured earlier than and through therapy over the course of 18 months.
Together with 10% weight reduction, the proportion of males with regular ranges of each complete and free testosterone rose from 53% to 77%. These findings point out that anti-obesity medicines can even have a constructive impact on the reproductive well being of males with weight problems or sort 2 diabetes.
“Outcomes from this research present that there’s a direct correlation between using anti-obesity medicines and testosterone ranges,” stated Portillo Canales. “Docs and their sufferers can now contemplate this class of medicines not just for the therapy of weight problems and to manage blood sugar, but additionally to profit males’s reproductive well being.”
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Anti-obesity medicines can normalize testosterone ranges in males (2025, July 14)
retrieved 14 July 2025
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