July 03, 2025
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Key takeaways:
- Two-thirds of respondents mentioned sufferers had close to or full symptom decision after Xiidra remedy.
- Delicate or average opposed occasions included blurred imaginative and prescient, burning/stinging and dysgeusia.
MINNEAPOLIS — Eye care practitioners have been glad with the efficiency of Xiidra in decreasing the indicators and signs of dry eye illness of their sufferers, based on a poster at Optometry’s Assembly.
The discovering got here from a survey of eye care practitioners with expertise prescribing Xiidra (lifitegrast ophthalmic answer 5%, Bausch + Lomb).
“Lifitegrast is an LFA-1 antagonist, which reduces irritation and may disrupt the inflammatory cycle that contributes to the pathophysiology of dry eye illness,” Melissa Barnett, OD, FAAO, FSLS, FBCLA, of UC Davis Well being Eye Heart, instructed Healio. “This survey is of eye care practitioners, each MDs and ODs, who examined real-world utilization and outcomes of lifitegrast within the remedy of sufferers with dry eye.”
Six ODs and 6 MDs accomplished Barnett and colleagues’ survey. On common, they reported treating a median of 1,288 sufferers with dry eye illness yearly. Lifitegrast was prescribed to a median of 21% of sufferers, of whom 24.1% had delicate illness, 50.5% had average illness, and 19.1% had extreme illness.
In keeping with the outcomes, 67% of eye care practitioners reported that their sufferers had close to or full symptom decision after 1 to three months of remedy with lifitegrast.
On a 10-point Likert scale, the typical satisfaction ranking for onset was 6.8, and the typical ranking for effectiveness was 6.6.
For the discount of indicators of dry eye illness, satisfaction rankings have been:
- Elevated tear movie breakup time: 5.8.
- Decreased conjunctival/corneal staining: 6.9.
- Elevated Schirmer check rating: 6.
- Elevated tear meniscus peak: 6.
For the discount of signs of dry eye illness, satisfaction rankings have been:
- Itching: 5.3.
- Dryness: 6.9.
- Burning: 6.3.
- Redness: 6.2.
- Ache: 6.3.
- Mild sensitivity: 6.5.
- Blurred imaginative and prescient: 6.8.
- Decreased Ocular Floor Illness Index severity: 7.
With the help of case information, enhancements have been discovered to be sustained throughout remedy for as much as 12 months.
Blurred imaginative and prescient, burning/stinging and dysgeusia have been reported as opposed occasions thought of to be associated to lifitegrast remedy, all delicate or average in severity.
“Findings from this real-world survey of eye care practitioners spotlight the fast and sturdy response related to lifitegrast for the remedy of sufferers with dry eye illness,” Barnett mentioned.
Sources/Disclosures
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Barnett M, et al. Actual-world expertise with lifitegrast ophthalmic answer in sufferers with dry eye illness: a supplier survey. Introduced at: Optometry’s Assembly; June 25-28, 2025; Minneapolis.
Disclosures:
Barnett studies serving on advisory boards and as a speaker for Bausch + Lomb.
