Key takeaways:
- There was no rebound impact in myopia development 1 12 months after stopping long-term put on of DOT lenses.
- The lenses additionally had optimistic leads to slowing myopia development in a Chinese language inhabitants.
SALT LAKE CITY — Myopia development doesn’t rebound after stopping long-term put on of SightGlass Imaginative and prescient’s myopia-controlling Diffusion Optics Expertise lenses, in line with a research offered right here.
The security and efficacy of Diffusion Optics Expertise (DOT) lenses have been additionally favorable in Chinese language youngsters in a separate research offered on the Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly.
To judge for a rebound impact after stopping DOT lens put on within the multicenter BIRCH research, 32 of 54 youngsters (imply age, 13.5 years; 57% ladies) who beforehand accomplished a 4-year trial carrying DOT lenses crossed over to plain single-vision spectacle lenses for 1 12 months, whereas the 22 youngsters within the management group continued to put on commonplace single-vision spectacle lenses.
One 12 months after switching, the 2 teams confirmed no important variations in axial elongation (0.17 mm in take a look at members vs. 0.13 mm in controls) or myopia development (–0.29 D in take a look at members vs. –0.14 D in controls).
“After cessation, axial size and refractive development reverted to age-normative charges and demonstrated no rebound impact,” Laughton mentioned. “This info may assist clinicians when selecting myopia management choices obtainable for his or her sufferers.”
SightGlass can be conducting a 24-month multicenter trial in China, which has larger prevalence and severity of myopia than North America. Within the CATHAY trial, DOT lenses have been evaluated towards commonplace single-vision spectacle lenses in 195 youngsters aged 6 to 13 years who have been randomly assigned DOT or single imaginative and prescient lenses in a 2:1 ratio.
In an interim evaluation at 12 months, those that wore DOT lenses had no important adjustments from baseline in axial size or cycloplegic spherical equal refraction. However those that wore single-vision lenses had important adjustments: a 0.35 ± 0.16 mm enhance in axial size (P = .03) and a –0.64 ± 0.16 D development in cycloplegic spherical equal refraction (P = .0001).
Total, these carrying DOT lenses had a 74% discount in axial size development and a 75% discount in cycloplegic spherical equal refraction development in contrast with the management group at 12 months.
“Based mostly on the 12-month outcomes of the CATHAY research and the outcomes from our North American CYPRESS pivotal research, eye care professionals can really feel assured that DOT lenses gradual the myopia development in youngsters from numerous populations,” Debbie Laughton, BSc, PhD, director of medical affairs at SightGlass Imaginative and prescient and co-author of each research, informed Healio.
“DOT lenses have now been obtainable commercially in Canada since 2022 and in China since 2023, and we’re seeing outcomes rising from ophthalmology and optometry clinics which can be being offered at worldwide conferences,” she mentioned. “These outcomes assist the findings of our medical trial outcomes, offering real-world proof that DOT lenses efficiently gradual myopia development.”
References:
- Hill JS, et al. Myopia development one-year after cessation of distinction modulation spectacle lenses. Introduced at: Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly; Might 4-8, 2025; Salt Lake Metropolis.
- Laughton D, et al. Management of myopia utilizing distinction modulation spectacle lenses in a Chinese language inhabitants: 12-month outcomes. Introduced at: Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly; Might 4-8, 2025; Salt Lake Metropolis.
