Transmasculine and gender-diverse people who use testosterone usually are not at elevated danger of gynecological most cancers within the first years of hormone remedy. That is evident from large-scale analysis by Amsterdam UMC, which was revealed in eClinicalMedicine.
The outcomes present necessary insights for well being care suppliers and transmasculine and gender-diverse people who’re contemplating beginning hormone remedy.
Transmasculine and gender-diverse individuals are registered as girls at beginning, however don’t really feel male, non-binary or in any other case at dwelling throughout the conventional picture of being a girl. A lot of them select to make use of testosterone: a hormone remedy that induces bodily adjustments which can be extra in step with their gender id and/or expression.
Researchers at Amsterdam UMC adopted 1,955 younger transmasculine and gender-diverse people, who used testosterone for a median of 5 years. They particularly investigated the danger of most cancers of the uterus, ovaries, vagina and vulva throughout testosterone use.
Asra Vestering, researcher at Amsterdam UMC, explains, “We discovered no elevated danger of those cancers in comparison with girls from the overall inhabitants. None of those cancers had been identified in the whole participant group. That is invaluable data for each well being care suppliers and transmasculine and gender-diverse people who find themselves contemplating beginning hormone remedy.”
It was additionally putting that in among the individuals the endometrium was nonetheless lively, or that indicators of ovulation had been noticed, regardless of using testosterone.
Wouter van Vugt, co-researcher at Amsterdam UMC, explains, “This isn’t solely related for long-term well being, but in addition implies that regardless of testosterone use, there’s nonetheless an opportunity of being pregnant. That’s the reason good gynecological care and contraceptive care stays important for this group, even after the beginning of hormone remedy.”
Lately, gender registration laws within the Netherlands has been relaxed, making surgical gender removing now not a requirement to legally change gender. Consequently, increasingly transmasculine and gender-diverse individuals are selecting to begin hormone remedy first, with out present process intercourse removing surgical procedure (instantly).
Though no definitive conclusions can but be drawn in regards to the results of long-term testosterone use, these findings supply reassurance for people who’ve began or need to begin testosterone use.
Vestering emphasizes, “This analysis gives necessary data for higher data and steerage of transmasculine and gender-diverse folks. On the identical time, follow-up analysis into the results of long-term testosterone use stays vital, in order that care could be additional tailor-made to security and high quality of life.”
Extra data:
Incidence of Gynaecological (Pre-)Malignancies and Endometrial Exercise in Transmasculine and Gender Numerous People Utilizing Testosterone: A Retrospective, Single-Centre Cohort Research, eClinicalMedicine (2025).
Quotation:
Research finds no elevated danger of gynecological most cancers with testosterone use after 5 years (2025, Might 12)
retrieved 12 Might 2025
from https://medicalxpress.com/information/2025-05-gynecological-cancer-testosterone-years.html
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