The Barcelona Institute for World Well being (ISGlobal) has launched HTGAnalyzer, a brand new, easy-to-use, quick and reproducible bioinformatics software for superior transcriptomic knowledge evaluation. Designed inside the R statistical surroundings, this package deal simplifies advanced analytical processes, making them accessible to professionals with out particular experience in bioinformatics.
Transcriptomic evaluation examines all messenger RNA molecules current in a cell at a given time, revealing which genes are expressed and in what amount. This data is essential in precision drugs, an method that seeks to tailor remedies to every affected person’s genetic and molecular profile.
Regardless of its medical potential, the implementation of transcriptomic strategies has been restricted not by knowledge technology, however by the complexity of the required bioinformatics evaluation.
A user-friendly software for clinicians and researchers
To deal with this problem, the ISGlobal staff has developed HTGAnalyzer: an automatic, free and user-friendly software for clinicians of varied specialties. Laia Díez-Ahijado was the lead writer of the software, which was collectively conceptualized by Natalia Rakislova and Robert Albero.
The examine, revealed in Computer systems in Biology and Drugs, demonstrates how HTGAnalyzer simplifies advanced transcriptomic workflows, together with knowledge import and normalization, pattern high quality management, differential gene expression evaluation, purposeful enrichment, tumor microenvironment profiling and survival evaluation. The software makes use of sufferers’ molecular knowledge to determine organic and medical variations, thereby supporting the medical interpretation of outcomes.
Validation utilizing real-world oncology knowledge
HTGAnalyzer was validated utilizing a number of datasets, together with RNA-seq knowledge from The Most cancers Genome Atlas (TCGA) and a cohort of sufferers with vulvar most cancers—a uncommon and typically aggressive malignancy.
Within the latter case, the software recognized differentially expressed genes, described their immunological profiles, and revealed genes and mobile pathways linked to this most cancers and to affected person survival. These findings spotlight the medical potential of HTGAnalyzer for producing data relevant to most cancers analysis, therapy, and prognosis.
With this growth, the analysis staff has achieved its objective of bridging the hole between advanced bioinformatic evaluation and the sensible wants of medical and analysis environments. HTGAnalyzer allows professionals with out superior bioinformatics experience to carry out important transcriptomic analyses which are more and more being utilized in personalised drugs to tell analysis, prognosis, and personalised remedies based mostly on the affected person’s molecular biology.
Extra data:
Laia Díez-Ahijado et al, HTGAnalyzer: An accessible R package deal with an internet interface for enhanced transcriptomic evaluation in precision drugs, Computer systems in Biology and Drugs (2025). DOI: 10.1016/j.compbiomed.2025.110772
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Person-friendly software streamlines transcriptomic knowledge evaluation for precision drugs purposes (2025, August 8)
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