Vaccination with the up to date COVID-19 mRNA vaccine containing the extreme acute respiratory syndrome coronavirus-2 omicron JN.1 lineage was not related to an elevated danger for 29 adversarial occasions, in accordance with a examine printed on-line July 28 in JAMA Community Open.
Niklas Worm Andersson, M.D., Ph.D., from Statens Serum Institut in Copenhagen, Denmark, and colleagues examined the affiliation between vaccination with JN.1-containing vaccines and the chance for 29 severe adversarial occasions tailored from prioritized lists of adversarial occasions of particular curiosity to COVID-19 vaccines. Consequence charges throughout the first 28 days after JN.1-containing vaccine administration (i.e., the chance interval) had been in comparison with end result charges throughout the remaining interval.
Contributors had been adults in Denmark advisable to obtain the 2024 to 2025 JN.1-containing booster vaccine who had beforehand acquired three or extra COVID-19 vaccine doses (1,012,400 people). The researchers discovered that throughout the 28-day danger interval after receipt of a JN.1-containing mRNA vaccine, there have been no important will increase within the charge of hospital contacts for any of 29 adversarial occasions in contrast with reference interval charges.
The incidence charge ratios had been 0.84 (95% confidence interval [CI], 0.76 to 0.94), 0.92 (95% CI, 0.76 to 1.13), and 1.12 (95% CI, 0.41 to three.10) for ischemic cardiac occasions, intracranial bleeding, and myocarditis, respectively.
“Though we analyzed a nationwide cohort, some outcomes, resembling erythema multiforme, occurred very not often throughout follow-up, with consequently decrease statistical precision, and a few outcomes, resembling transverse myelitis, couldn’t be statistically in contrast,” the authors write.
Extra data:
Niklas Worm Andersson et al, Security of JN.1-Up to date mRNA COVID-19 Vaccines, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.23557
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COVID-19 mRNA vaccine concentrating on omicron JN.1 lineage secure (2025, August 6)
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