Key takeaways:
- Adolescents with chubby or impaired glucose tolerance had decrease BMD on the tibia than these with regular weight.
- Some bone turnover markers have been decrease for these with diabetes or chubby vs. regular weight.
SAN FRANCISCO — The event of weight problems and sort 2 diabetes throughout childhood could inhibit bone formation and will result in the next threat for fractures in maturity, in line with a presenter at ENDO 2025.
Bone mineral density tends to be regular or larger for adults with weight problems and sort 2 diabetes than these with regular weight and no diabetes, stated Fida Bacha, MD, professor of pediatrics within the Youngsters’s Vitamin Analysis Heart at Baylor School of Medication and within the division of pediatric endocrinology and diabetes at Texas Youngsters’s Hospital in Houston. Nevertheless, Bacha stated adults with sort 2 diabetes even have larger threat for fractures than individuals with out diabetes, and alterations in bone construction at a younger age could clarify worsened fragility later in life.
“We examined two hypotheses. One was that youth with weight problems and sort 2 [diabetes] have decrease bone accrual over 1 yr in contrast with youthful individuals with regular weight,” Bacha stated throughout a presentation. “The second was that folks with weight problems in grownup sort 2 diabetes have much less enhance in bone power.”
Researchers performed a longitudinal research enrolling 48 adolescents, all of whom have been in Tanner stage 2, 3 or 4 at enrollment (imply age, 15.5 years; 54.2% women). Among the many cohort, 27% had regular weight, 31% had chubby and regular glucose tolerance and 42% had chubby with impaired glucose regulation, which included kids with a analysis of prediabetes or sort 2 diabetes. Information on physique composition, cardiorespiratory health and glycemic profile have been collected at baseline. Bone microarchitecture was measured on the distal tibia and radius utilizing high-resolution peripheral quantitative CT at baseline, 6 months and 1 yr.
At baseline, 25-hydroxyvitamin D ranges have been decrease amongst youths with impaired glucose tolerance (14.9 ng/mL) than these with chubby and regular glucose tolerance (26.4 ng/mL) and regular weight (32.1 ng/mL; P < .001 for each). There have been no vital variations in calcium, phosphorus, alkaline phosphatase and parathyroid hormone between the teams.
Insulin resistance was negatively correlated complete volumetric BMD on the tibia (r = –0.43; P = .002) and radius (r = –0.31; P = .02). Insulin resistance was additionally negatively correlated with trabecular thickness on the tibia (r = –0.43; P = .003).
At 1 yr, volumetric BMD on the tibia was decrease for adolescents with chubby and regular glucose tolerance (P = .002) and people with IGT (P = .011) than youths with regular weight (P = .016 for time by group interplay). Tibia complete bone modulus was additionally decrease for teenagers with chubby and regular glucose (P = .004) and people with IGT (P = .038) than adolescents with regular weight (P = .034 for time by group interplay). The three teams didn’t differ in radius trabecular bone modulus and complete bone modulus at 1 yr.
“General, we noticed a rise in volumetric bone density over 12 months, and there was additionally a rise in complete bone modulus over 12 months,” Bacha stated of the BMD and bone modulus change for the total research group.
Adolescents with regular weight had the next procollagen sort 1 N-terminal propeptide (P1NP) stage (P = .008) and larger osteocalcin (P = .04) than these with chubby and regular glucose tolerance and youths with IGT. Elevated P1NP was positively correlated with % enhance in complete volumetric BMD from baseline to 1 yr at each the tibia (r = 0.037; P = .024) and radius (r = 0.67; P < .001).
Bacha stated bigger research throughout a wider vary of glycemic ranges are wanted to substantiate the findings.
Sources/Disclosures
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Bacha F, et al. Summary OR28-07. Introduced at: ENDO annual assembly; July 12-15, 2025; San Francisco.
Disclosures:
Bacha stories no related monetary disclosures.
