Key takeaways:
- A single drop of Miebo had no vital affect on corneal measurements for as much as 60 minutes.
- Just one affected person had lens energy change larger than 0.5 D after Miebo.
SALT LAKE CITY — One drop of Miebo had no vital affect on presurgical corneal measurements taken inside 60 minutes of instillation, in accordance with a research introduced on the Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly.
“We all know from the animal [pharmacokinetic] research that have been carried out that [perfluorohexyloctane ophthalmic solution] can hold on the floor or within the tears for as much as 6 hours,” research creator Kayla Karpuk, OD, of Vance Thompson Imaginative and prescient, Sioux Falls, South Dakota, informed Healio. “We needed to raised perceive, is that molecule impacting biometric measurements in an acute time period?”
The discovering might assist precisely interpret corneal measurements earlier than cataract surgical procedure.
Karpuk and Tanner Ferguson, MD, performed a potential observational research of 62 eyes of 31 sufferers with regular tear movie based mostly on slit lamp examination. Earlier than instilling Miebo (perfluorohexyloctane ophthalmic resolution, Bausch + Lomb), biometry measurements have been taken with Pentacam (Oculus) and Argos (Alcon); measurements have been then taken once more quarter-hour and 60 minutes after instillation.
Karpuk and Ferguson in contrast the typical keratometry, corneal cylinder and axis from each units at every time level and in contrast the share of change in lens energy with the CC60WF IOL (Alcon) and the typical change in manifest refraction spherical equal between every time level.
The drops largely had no vital affect on the measurements. The one considerably totally different worth was the typical keratometry worth with Pentacam after quarter-hour (P < .04046).
Lens powers focused for emmetropia have been steady in 73% of sufferers from baseline to fifteen minutes and remained steady in 75% of sufferers at 60 minutes.
Just one affected person had a lens energy change larger than 0.5 D, with a 1 D change at quarter-hour solely. The typical adjustments in manifest refraction spherical equal have been 0.1005 D at quarter-hour and 0.1003 D at 60 minutes.
“I believe that is form of a reassurance for us,” Karpuk mentioned. “This helps to offer peace of thoughts that any adjustments that we see on biometry are actually associated to the underlying ocular floor illness and never altering because of the molecule of [perfluorohexyloctane ophthalmic solution].”
For extra data:
Kayla Karpuk, OD, could be reached at kayla.karpuk@vancethompsonvision.com.
Sources/Disclosures
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Karpuk Ok, et al. The affect of a single drop of perfluorohexyloctane ophthalmic resolution (Miebo) has on biometry measurements and intraocular lens calculations. Offered at: Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly; Might 4-8, 2025; Salt Lake Metropolis.
Disclosures:
Karpuk stories consulting for Tarsus. Please see the research for all different authors’ related monetary disclosures. The research was funded by a grant from Bausch + Lomb.
