You recognize these nights once you’re alleged to be sleeping however as an alternative you’re deep in a YouTube rabbit gap? That’s precisely the place I used to be once I first heard about NMN. I used to be watching Huberman’s podcast (yeah, I’m that man who watches neuroscience movies at 1 AM) and the way in which he talked about these things made me sit up and listen. Plus, hitting 34 had me feeling like somebody swapped my physique’s working system from Home windows XP to Vista, the whole lot simply felt… slower.
So what’s NMN? It’s principally vitamin B3’s overachieving cousin that helps your physique make one thing known as NAD+. And sure, I needed to observe saying “nicotinamide adenine dinucleotide” about 47 occasions earlier than I may say it with out stumbling. The entire thing gave the impression of a kind of too-good-to-be-true complement advertisements, however once you’re coping with fitness center restoration that feels such as you obtained hit by a truck and mind fog thicker than San Francisco marine layer, you begin getting determined.
Look, I’m often the man rolling my eyes at complement claims. Half the stuff out there’s simply advertising and marketing BS designed to separate you out of your cash. However NMN had precise analysis behind it, not just a few dude on Instagram flexing subsequent to a bottle. Research have proven that NMN supplementation can improve NAD+ ranges and enhance varied age-related well being markers. The essential concept is that NAD+ is like your mobile battery, and we begin working on low energy mode as we become old. Enjoyable occasions, proper?
I made a decision to commit to three months testing out Renue by Science’s Pure Powder NMN. I figured if I used to be going to do that, I’d do it proper, lengthy sufficient to know if it really labored or if I used to be simply funding somebody’s yacht cost. Spoiler alert: I’m nonetheless taking it 6 months later, so both it’s working, or I’ve developed the world’s costliest placebo dependancy.
Buckle up, as a result of this journey obtained attention-grabbing…
What Truly Is Renue by Science Pure Powder NMN?
I first seen Renue by Science when Huberman talked about on Twitter (sorry, X, nonetheless can’t get used to that) that he takes their NMN. That caught my consideration as a result of the man doesn’t simply endorse random stuff. The truth is, he’s fairly selective about what he places in his physique. For many who’ve been residing beneath a rock, NMN stands for Nicotinamide Mononucleotide, principally a molecule that helps your physique produce NAD+.
Consider NAD+ like WD-40 on your cells. It retains the whole lot working easy, from power manufacturing to DNA restore to retaining your cells speaking to one another correctly. The crappy half? NAD+ ranges tank as we age, which explains why hangovers hit completely different in your 30s than they did at 21. Analysis exhibits that by center age, our NAD+ ranges have plummeted to half that of our youth.
You ever discover how children can run round all day, sleep for six hours, and bounce again like nothing occurred? In the meantime, you sleep improper on a Tuesday and your neck hurts till Friday. That’s partly as a result of their NAD+ ranges are by means of the roof in comparison with us older people. Research point out that by the point you hit 40, your NAD+ ranges are about half what they have been at 20. By 60? You’re working on fumes, buddy
What obtained me concerned about Renue by Science particularly was their no-BS method. They’re not promising you’ll reverse age like Benjamin Button or all of the sudden develop superpowers. They’re simply making an attempt to assist your physique preserve the NAD+ ranges it had once you have been youthful. Fairly affordable, really.
They’ve obtained just a few completely different variations, liposomal and sublingual powder. I went with the sublingual powder as a result of I appreciated with the ability to management precisely how a lot I used to be taking. Plus, the thought of little fats bubbles (that’s what liposomes are) floating round in my complement appeared bizarre, despite the fact that the science is strong.
Sublingual NMN Vs. Liposomal NMN
The Sublingual vs. Liposomal Showdown
Liposomal NMN: Okay, so these guys wrap the NMN in tiny fats bubbles. Sounds ridiculous, but it surely’s really fairly good. Your abdomen acid is principally xenomorph blood, it destroys the whole lot. These fats bubbles act like tiny bodyguards, getting the NMN previous your abdomen’s safety checkpoint. The nerds in lab coats say this implies higher absorption, and who am I to argue? Renue by Science additionally makes a extremely rated Liposomal NMN product.
The perks:
- Survives the abdomen acid gauntlet higher
- Supposedly absorbs extra effectively
- Good in the event you hate the style of sublingual powder
- Some folks swear it really works quicker
However right here’s the factor. Liposomal something tends to price extra as a result of the manufacturing course of is extra complicated. You’re paying for these fancy fats bubbles. Whether or not it’s price the additional money is as much as you and your pockets.
Sublingual NMN: That is what I selected. You dump the powder beneath your tongue and let it dissolve. It tastes… properly, it tastes such as you’d anticipate a scientific compound to style. Not profitable any taste awards. However right here’s why I picked it:
- Goes straight into your bloodstream, no digestive detours. The blood vessels beneath your tongue are principally a freeway to your system. No tolls, no visitors, simply zoom.
- Kicks in quicker (or at the very least that’s the speculation). Some folks report feeling results inside days reasonably than weeks.
- Skips the liver’s filtering system completely. Your liver is like that pal who at all times needs to “assist” however finally ends up making issues difficult. Sublingual supply bypasses that entire mess.
- I can modify my dose simpler. Began with 500mg of Renue by Science Pure Powder, and finally labored as much as a gram. Attempt doing that with capsules with out going insane.
Full disclosure: I really began mixing mine into Greek yogurt after studying that’s what David Sinclair does. Certain, it’s not technically “sublingual” anymore, but it surely beats holding bitter powder beneath my tongue whereas making an attempt to not swallow for two minutes.
What sealed the deal for me was their testing. They really third-party check their stuff and comply with correct manufacturing requirements. Within the wild west of dietary supplements, that’s like discovering a unicorn. Analysis on NMN dietary supplements discovered that almost all of what’s on Amazon is rubbish. One examine discovered that out of 21 manufacturers, solely 3 really contained the NMN they claimed. The remaining? Costly flour, principally. It’s not like this issues a lot anymore since Amazon has banned all gross sales of NMN for no matter purpose.
After taking 1 gram every day, right here’s what I seen within the first month:
- Truly had power previous 3 PM (miracle)
- Mind fog began clearing up
- Didn’t need to homicide folks throughout nerve-racking conferences
- Might push tougher on the fitness center with out feeling destroyed
- Usually felt much less like a zombie
RELATED READING: 7 Finest NMN Dietary supplements of 2025 – A Biohacker’s Assessment
My 90-Day NMN Journey
I began this entire experiment with a mixture of skepticism and hope. Stored detailed notes as a result of, properly, I’m that type of nerd. Each morning, I’d dump my dose into Greek yogurt (shoutout to Sinclair’s protocol for that tip) and wait to see if I’d all of the sudden really feel 25 once more.
Month 1: The “Is This Working?” Part
Weeks 1-2: The primary couple weeks have been fairly anticlimactic. No sudden burst of power, no feeling like Bradley Cooper in Limitless. Simply me, consuming costly yogurt and questioning if I’d been suckered. However I saved at it as a result of Rome wasn’t inbuilt a day, and apparently neither is mobile rejuvenation.
I did discover one factor although. My morning routine felt barely much less torturous. Often, the alarm goes off and I ponder whether or not unemployment would actually be that dangerous. However round day 10, I seen I wasn’t hitting snooze as a lot. Small win, however I’ll take it.
Began monitoring the whole lot: power ranges on a scale of 1-10, exercise efficiency, temper, sleep high quality, what number of occasions I needed to throw my laptop computer out the window throughout Zoom calls. You recognize, the necessary metrics.
Weeks 3-4: Then issues obtained attention-grabbing. Very first thing I seen? I wasn’t dragging myself away from bed like a Strolling Useless additional anymore. Morning me and night me began feeling like the identical particular person, no extra Jekyll and Hyde power crashes.
The three PM stoop that often had me mainlining espresso? Gone. Not utterly vanished, however manageable sufficient that I may really perform with out my afternoon espresso IV drip.
My sleep additionally obtained bizarre, however good bizarre. I’d go to sleep quicker and get up feeling like I’d really slept, not simply quickly died for 8 hours. Began having extra vivid desires too, which was trippy. Undecided if that’s associated, however I’m counting it as an information level.
One sudden factor: my joints felt higher. I’ve obtained a cranky left knee from years of pretending I used to be an athlete. Often, it complains once I squat. By week 4, it was noticeably quieter. Coincidence? Possibly. However I wasn’t complaining.
Month 1 Verdict: Nothing earth-shattering, however sufficient small wins to maintain me going. Sort of like once you begin figuring out and don’t see muscle positive factors but, however your denims match a tiny bit higher.
The cumulative impact was what shocked me. No single day felt dramatically completely different, however evaluating week 4 to week 1? Evening and day. It’s like somebody had been slowly dimming the lights in my life, and NMN was progressively turning them again up.
Month 2: Issues Get Actual
Weeks 5-6: That is when stuff began getting attention-grabbing. That refined morning power enhance from month one? It leveled up. I went from “functioning human” to “really passionate about being awake.” My productiveness shot by means of the roof, knocked out work duties that often took all day in half the time.
Began noticing I used to be in a greater temper general. Not artificially completely happy like I’d mainlined cotton sweet, simply… secure. Even. My spouse commented that I appeared “much less grumpy,” which in marriage converse means “considerably much less of an asshole.”
Espresso consumption dropped from 4 cups to 2. Not as a result of I used to be making an attempt to chop again, I simply didn’t want it. That third cup that was once necessary at 2 PM? Forgot about it utterly most days.
Weeks 7-8: The fitness center is the place issues obtained loopy. I’ve been lifting for years, so I do know my limits fairly properly. All of the sudden, these limits appeared… negotiable. Restoration time between units shortened, and the same old next-day soreness was extra like gentle discomfort. Began hitting PRs I hadn’t touched in years.
However right here’s the bizarre half. It wasn’t simply bodily power. My endurance improved too. Often, by the tip of a exercise, I’m able to crawl to my automotive. Now I used to be ending sturdy, typically even including additional units as a result of I felt good. Who was I changing into?
Then got here the sudden bonus: my pores and skin. I’m a dude in my 30s, so skincare isn’t precisely my forte, however even I seen my face seemed much less… drained? My spouse really requested if I’d began utilizing her fancy face cream. Nope, simply costly powder in my breakfast.
Pals began noticing too. Received the “you look good, have you ever misplaced weight?” query a number of occasions. Hadn’t misplaced a pound, however one thing about my general look was completely different. Extra alive, I suppose.
Month 2 Verdict: Okay, now we’re speaking. This wasn’t placebo territory anymore. Too many constant enhancements throughout too many areas.
The psychological readability was changing into my favourite profit. Work tasks that used to really feel overwhelming turned manageable. I used to be making connections quicker, fixing issues simpler, typically feeling like my mind had gotten a software program replace.
Month 3: The New Regular
Weeks 9-10: The whole lot from month two caught round and settled in as my new baseline. The power wasn’t a fluke, it was constant, dependable, like upgrading from dial-up to fiber web. Psychological readability was the actual MVP although. Work tasks that used to really feel like climbing Everest in flip-flops turned manageable hills.
Began taking over extra tasks at work as a result of I really had the bandwidth. My boss seen. My annual assessment was arising, and for the primary time in years, I wasn’t dreading it.
Sleep high quality continued to enhance. I’d turn into a kind of annoying morning individuals who really enjoys dawn. Previous me would have needed to punch present me within the face.
Weeks 11-12: By the tip of three months, the adjustments have been plain. Pals began asking what I used to be doing in another way. One buddy accused me of secretly doing TRT (testosterone alternative remedy). Nope, simply fancy vitamin B3, my dude.
One of the best half? It wasn’t simply bodily. My temper was persistently higher. Not manic completely happy, simply… secure. Like somebody had lastly balanced the chemical substances in my mind aquarium.
Power ranges stayed constant all through the complete day. No crashes, no determined want for afternoon caffeine, no falling asleep throughout Netflix at 9 PM like an previous man. I felt like I’d reclaimed about 3-4 helpful hours per day simply from not being exhausted.
Month 3 Verdict: These items works. Interval. Not in a magical unicorn method, however in a “holy crap, I really feel like a useful human once more” method.
The compound impact over 90 days was outstanding. If month 1 was planting seeds and month 2 was seeing sprouts, month 3 was having fun with the backyard. The whole lot labored higher: physique, mind, temper, power. It wasn’t dramatic, it was systematic enchancment throughout the board.
RELATED READING: Andrew Huberman’s Full Every day Complement Record
What NMN Truly Does (In response to Science and My Expertise)
The Anti-Getting older Factor
Look, I’m not gonna sit right here and inform you NMN is the fountain of youth. However the science on NAD+ decline and getting old is legit. Quite a few research have demonstrated that boosting NAD+ ranges will increase insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. By retaining these ranges up, you’re principally giving your cells the assets they should not suck at their jobs.
Right here’s what the analysis says occurs when NAD+ ranges drop:
- Mitochondria (your mobile energy vegetation) get sluggish
- DNA restore mechanisms decelerate
- Irritation will increase
- Mobile communication breaks down
- Power manufacturing turns into inefficient
It’s like making an attempt to run a contemporary laptop on Home windows 95. Technically it really works, however the whole lot is painfully gradual and crashes continuously. In mouse research, NMN has been capable of suppress age-associated weight achieve, improve power metabolism and bodily exercise, enhance insulin sensitivity, enhance eye perform, and forestall age-linked adjustments in gene expression.
What I seen:
- Higher power (clearly)
- Clearer pondering
- Much less irritation after exercises
- Pores and skin that doesn’t appear to be leather-based
- Sooner restoration from the whole lot (exercises, late nights, stress)
- Common sense of vitality that had been lacking
In response to scientific trials in people, NMN supplementation at doses of 300-900mg every day elevated blood NAD ranges, improved bodily efficiency, and even diminished organic age markers. These advantages align with what researchers are seeing in research. We’re not speaking about reversing getting old, we’re speaking about getting old higher. Large distinction.
Power and Metabolism
This was the massive one for me. NAD+ is essential for turning meals into power. When it’s low, you’re feeling such as you’re working on fumes even after consuming. By supplementing with Renue by Science Pure Powder NMN, my physique appeared to recollect find out how to really use the gasoline I used to be giving it.
The science will get fairly dense right here, however principally, NAD+ is concerned in one thing known as the Krebs cycle (or citric acid cycle if you wish to sound fancy at events). That is how your cells convert vitamins into ATP, which is principally mobile forex. Low NAD+ means inefficient power manufacturing. Increase NAD+, and all of the sudden your mobile economic system is booming.
Actual-world outcomes:
- Regular power all day (no extra 3 PM face-plants)
- Higher exercise efficiency
- Simpler time sustaining weight
- Much less reliance on caffeine
- Improved endurance for each bodily and psychological duties
- No extra feeling exhausted after consuming
That final one was large for me. You recognize that post-lunch coma feeling? Gone. I may eat a full meal and nonetheless perform like a human being afterward.
Mind Perform
The cognitive stuff shocked me most. I anticipated bodily advantages, however the psychological readability was a game-changer. It’s like somebody cleaned the windshield I’d been wanting by means of for years.
Your mind is an power hog. It makes use of about 20% of your physique’s complete power regardless of being solely 2% of your physique weight. When NAD+ ranges are low, your mind is without doubt one of the first issues to undergo. Increase NAD+, and all of the sudden your mind has the assets it must perform correctly.
What improved:
- Focus throughout lengthy work classes
- Higher reminiscence (stopped strolling into rooms and forgetting why)
- Sooner problem-solving
- Much less psychological fatigue
- Improved temper stability
- Higher stress administration
- Enhanced creativity (bizarre however true)
The main focus enchancment was notably noticeable. I may sit down and work for 2-3 hours straight with out my thoughts wandering to YouTube or checking my telephone each 5 minutes. For somebody with the eye span of a caffeinated squirrel, this was revolutionary.
RELATED READING: Dr. David Sinclair’s Anti-Getting older Complement Record
The Renue by Science Breakdown
High quality and Purity
Renue by Science doesn’t fiddle. The truth is, they’re thought-about the very best of the very best. Renue is third-party examined, manufactured in legit services, and even Andrew Huberman trusts them, that’s a reasonably strong endorsement. After that examine exhibiting most Amazon NMN dietary supplements have been principally costly flour, I’m glad I went with a good model.
Right here’s what units them aside:
- Each batch is examined for purity
- No fillers or bizarre components
- Manufactured in FDA-registered services
- Certificates of Evaluation out there
- Constant high quality throughout batches
I really emailed them as soon as with a query about storage (yeah, I’m that man), they usually responded inside a day with detailed data. That stage of customer support within the complement world is uncommon.
Worth Actuality Examine
Let’s speak cash. At round $64 for 100 grams, Renue by Science NMN is surprisingly reasonably priced as a result of that lasts 3-6 months relying in your dose. Break it down every day, and it’s a lot lower than your fancy espresso behavior. Plus, use code ‘brainflow’ for 15% off (you’re welcome). Whenever you break it down, we’re speaking just some nickels and dimes per day.
Right here’s my price breakdown:
- 100g bottle = $64 (or $55 with low cost)
- At 1g per day = 100 days’ provide, 200 days’ provide if doing 500mg
- Every day price = $0.64 (or $0.55 with low cost)
- Month-to-month price = $21 (or $19 with low cost)
Examine that to:
- Every day Starbucks = $5-7
- Gymnasium membership = $50-100/month
- Netflix subscription = $15/month
- These different dietary supplements gathering mud = Priceless
Whenever you body it like that, it’s really fairly affordable for one thing that considerably improves your high quality of life.
Truly Utilizing It
Useless easy. Measure your dose, dump it beneath your tongue or in meals, accomplished. No difficult timing, no bizarre restrictions. I’ve tried dietary supplements that required a PhD to determine the dosing schedule, this isn’t considered one of them.
My routine:
- Get up
- Make Greek yogurt
- Dump 1g NMN on prime (or let it dissolve beneath the tongue for higher absorption)
- Combine and eat
- Go about my day feeling like a useful human
That’s it. No fasting necessities, no biking on and off, no difficult stacking protocols. Simply consistency.
Professional tip: Get a small digital scale that measures in milligrams. The inside track they supply is ok, however I desire precision. Plus, it makes you’re feeling like a scientist, which is enjoyable.
The Not-So-Nice Elements
Let’s preserve it actual, it’s not all sunshine and enhanced mitochondrial perform. I’ve seen just about no downsides, however some folks expertise:
- Abdomen points (principally in the event you take an excessive amount of too quick). Begin low, work your method up. Your intestine wants time to regulate to new issues.
- Bizarre fatigue at first (your physique adjusting). This hit me round day 4-5. Felt unusually drained for no purpose. Pushed by means of, and it went away by week 2.
- Complications (keep hydrated). NMN can have a light diuretic impact. Drink extra water than you assume you want.
- Some folks report flushing or feeling heat. I by no means skilled this, but it surely’s apparently innocent if it occurs.
- The style. Oh god, the style. When you’re doing sublingual, put together for bitterness that’ll make you query your life selections. Therefore why I combine it with meals.
Additionally, in the event you’re on drugs or have well being points, speak to your physician. I’m just a few man on the web sharing his expertise, not a medical skilled. Don’t sue me in the event you sprout a 3rd arm or one thing. Medical trials have proven NMN is mostly secure at doses as much as 1,200mg every day, however everybody’s completely different.
What Different Individuals Say
I dove deep into critiques earlier than beginning, and the experiences have been fairly constant. Spent hours on Reddit threads studying actual person experiences, and the sample was clear. Latest human trials have proven that NMN supplementation improves bodily perform, insulin sensitivity, telomere size, and presumably listening to throughout getting old.
Widespread constructive experiences:
- Power enhancements (most typical)
- Higher restoration from train
- Improved temper and focus
- Higher sleep high quality
- Pores and skin enhancements
- Lowered irritation
One runner stated their restoration time halved. They went from needing 2 relaxation days between lengthy runs to with the ability to run consecutive days. A 60-something reported feeling mentally sharper than that they had in years, stated it was like “lifting a fog” from their mind. Research have proven related cognitive advantages, with NMN enhancing mind blood circulate and dealing reminiscence in aged mice to ranges just like younger mice.
However let’s be actual, some folks felt nothing even after months. That’s dietary supplements for you, your mileage might range. Our bodies are bizarre, biochemistry is particular person, and what works for one particular person would possibly do jack squat for an additional.
The destructive critiques principally complained about:
- No noticeable results
- Upset abdomen
- Too costly
- Style (for sublingual customers)
Curiously, most destructive critiques have been from individuals who solely tried it for just a few weeks. The constructive critiques principally got here from individuals who caught with it for at the very least 2-3 months. Make of that what you’ll.
Six Months Later: The Lengthy-Time period Replace
I’m scripting this replace 6 months into my NMN journey, and I needed to share what occurs after the honeymoon part ends.
The excellent news? The advantages have caught round. Power ranges stay persistently increased than my pre-NMN days. Psychological readability remains to be on level. Gymnasium efficiency continues to impress me (and possibly annoy my youthful fitness center buddies).
Some advantages have really elevated. My sleep high quality saved enhancing previous the 3-month mark. Now I’m a kind of weirdos who wakes up earlier than their alarm feeling refreshed. Previous me is rolling in his grave.
The not-so-good information? The dramatic month-to-month enhancements have plateaued. Month 6 feels so much like month 4, which felt so much like month 3. The enhancements appear to have hit a ceiling, which is sensible. You may solely optimize a lot.
I’ve experimented with dosing. Tried 1.5g for a month (no extra profit, simply dearer). Tried 500mg for a month (felt a slight dip in power however nothing dramatic). Settled again at 1g every day as my candy spot.
Additionally tried biking off for 2 weeks to see what would occur. By day 10, I seen the afternoon power dips returning. Mind fog began creeping again. Exercise restoration took longer. Nothing catastrophic, however sufficient to persuade me that these things is definitely doing one thing past placebo. In brief, Renue by Science Pure Powder NMN works.
Backside Line: Is It Price It?
After 6 months on NMN, I’m a believer. Not in a cult-follower method, however in a “this legitimately improved my high quality of life” method. Is it a miracle remedy? Nah. Is it a useful gizmo for feeling much less like rubbish as you age? Completely.
The science is promising however nonetheless growing. We don’t have 50-year research on these things. However primarily based on what we learn about NAD+ and getting old, plus my very own expertise, I’m comfy persevering with. The analysis is advancing quickly, with a number of human scientific trials underway to raised perceive NMN’s results on human getting old.
Who ought to do this:
- Individuals over 30 feeling the consequences of getting old
- Anybody coping with continual fatigue
- Athletes searching for higher restoration
- Individuals who need to optimize their well being
- Anybody curious in regards to the science
Who ought to perhaps skip it:
- Individuals beneath 25 (your NAD+ might be high quality)
- Anybody with severe well being circumstances (speak to your physician)
- Individuals anticipating miracles
- Anybody on a brilliant tight finances
When you’re on the fence with Renue by Science NMN, right here’s my recommendation: attempt it for 3 months. That’s sufficient time to know if it’s working for you. Use code ‘brainflow’ for 15% off, monitor how you’re feeling, and see what occurs. Worst case, you’re out just a few hundred bucks. Finest case, you’re feeling like a useful human once more.
Simply bear in mind, this isn’t a alternative for consuming proper, exercising, and sleeping. It’s a complement, not a miracle. However typically, an excellent complement is precisely what you’ll want to tip the scales from “surviving” to “thriving.”
The best way I see it, we spend cash on all types of issues that don’t materially enhance our lives. That streaming service you barely use, the fitness center membership you overlook about, these dietary supplements gathering mud in your cupboard. Not less than with NMN, I’m getting tangible advantages that make day by day higher.
Now in the event you’ll excuse me, I must go combine my morning NMN into some yogurt and fake it doesn’t style like science. As a result of feeling this good is price choking down some bitter powder with my breakfast.
Able to attempt it your self? Seize your Renue by Science Pure Powder NMN with code ‘brainflow’ for 15% off your order.
