Folks with an underactive thyroid could have an elevated threat of growing small intestinal bacterial overgrowth (SIBO), a threat that could be diminished with thyroid hormone remedy, in accordance with a research being introduced Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
“We now know that individuals with hypothyroidism, particularly these with autoimmune thyroiditis, usually tend to develop SIBO, however this threat seems to be mitigated in these taking thyroid drugs,” stated Ruchi Mathur, M.D., Director of the Diabetes Outpatient Remedy and Training Middle and Director of Scientific Operations of Medically Related Science and Know-how, at Cedars-Sinai in Los Angeles, Calif.
Mathur stated their analysis additionally suggests there could also be a microbiological mechanism driving this affiliation, which may result in extra customized therapies.
The researchers investigated the connection between SIBO and hypothyroidism in individuals older than 18 who beforehand underwent higher endoscopy with out colon prep and reported residing with hypothyroidism in addition to controls. Topics had been recruited by means of their flagship REIMAGINE research.
They analyzed small bowel fluid samples from 49 individuals with hypothyroidism and 323 with out the situation and carried out DNA sequencing to determine microbial species. The outcomes confirmed that individuals with hypothyroidism had a considerably greater prevalence of SIBO in comparison with controls (33% vs. 15%).
Mathur and colleagues then additional evaluated 4 teams: SIBO-positive with hypothyroidism, SIBO-negative with hypothyroidism, SIBO-positive with out thyroid illness, and SIBO-negative with out thyroid illness.
The evaluation confirmed completely different patterns of micro organism within the intestine relying on an individual’s thyroid standing and co-occurrence of SIBO.
Individually, they carried out a large-scale evaluation of medical information from the TriNetX database, which seemed on the 10-year dangers of growing SIBO in individuals with hypothyroidism or autoimmune thyroiditis in comparison with matched controls. The dangers had been additionally mitigated in individuals taking levothyroxine.
“Outcomes confirmed the danger of growing SIBO in topics with hypothyroidism is 2.2 instances greater than the danger in a matched management cohort and was 2.4 instances greater in these with autoimmune thyroiditis in comparison with a matched management group. This echoes our findings within the REIMAGINE cohort,” famous the research’s presenting writer, Margaret Wei, M.D., of the Cedars-Sinai Medical Middle Endocrine Fellowship Program.
“These findings open the door to new screening and prevention methods. For instance, docs could start to watch thyroid well being extra carefully in sufferers with SIBO, and vice versa. It additionally helps the concept bettering intestine well being may have far-reaching results past digestion, presumably even serving to to stop autoimmune illnesses, reminiscent of Hashimoto’s,” Mathur stated. “As analysis continues, this might result in extra customized care and earlier interventions for at-risk people.”
Quotation:
Thyroid remedy could enhance intestine well being in individuals with hypothyroidism (2025, July 12)
retrieved 12 July 2025
from https://medicalxpress.com/information/2025-07-thyroid-treatment-gut-health-people.html
This doc is topic to copyright. Other than any honest dealing for the aim of personal research or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.
