Radiation remedy can promote amphiregulin, which will increase progress of metastases

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Radiation therapy can promote amphiregulin, which increases growth of metastases

Radiation remedy can promote the epidermal progress issue receptor (EGFR) ligand amphiregulin, which will increase progress of present metastases in sufferers with superior stable tumors, in keeping with a examine just lately revealed on-line in Nature.

András Piffkó, M.D., from the College of Chicago, and colleagues explored the possibly deleterious impact of radiation in selling metastasis in sufferers with superior stable tumors who acquired stereotactic physique radiotherapy to a number of metastatic websites. Gene expression was examined in 22 matched preradiotherapy and postradiotherapy biopsies for irradiated metastases.

The researchers discovered that the EGFR ligand amphiregulin was induced by radiotherapy in tumor cells; amphiregulin reprograms EGFR-expressing myeloid cells towards an immunosuppressive phenotype and might cut back phagocytosis. Amphiregulin was concerned in three of the highest 20 upregulated gene pathways correlating with distant tumor development. Sufferers whose tumors expressed elevated amphiregulin had shorter progression-free and general survival. Native radiotherapy decreased the variety of lung metastases however elevated their dimension by way of secretion of amphiregulin; gene knockout prevented this impact. Related findings have been seen in mouse lung metastasis fashions and have been overcome by a blockade of amphiregulin.

“Apparently, the mixture of radiation and amphiregulin blockade decreased each tumor dimension and the variety of metastatic websites,” senior writer Ralph R. Weichselbaum, M.D., additionally from the College of Chicago, stated in a press release.

A number of authors disclosed ties to the biopharmaceutical business.

Extra info:
András Piffkó et al, Radiation-induced amphiregulin drives tumour metastasis, Nature (2025). DOI: 10.1038/s41586-025-08994-0

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Radiation remedy can promote amphiregulin, which will increase progress of metastases (2025, July 12)
retrieved 12 July 2025
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