Utilizing tirzepatide and menopause hormone remedy on the similar time results in elevated weight reduction in postmenopausal ladies with obese or weight problems in contrast to make use of of tirzepatide remedy alone, based on a examine being introduced Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
“These knowledge are the primary to point out the mixed use of tirzepatide and menopause hormone remedy considerably will increase remedy effectiveness in postmenopausal ladies,” mentioned Regina Castaneda, M.D., analysis fellow for the Division of Endocrinology on the Mayo Clinic in Jacksonville, Fla.
“Earlier research of the remedy semaglutide discovered related outcomes. Reaching these outcomes with a second weight problems remedy could point out a broader efficacy pattern for pairing these two courses of medicines.”
Menopause-related hormonal adjustments typically end in elevated stomach fats, decreased muscle mass and altered vitality expenditure, which results in weight acquire and places tens of millions of girls in danger for growing coronary heart illness and different critical well being points.
To substantiate the speculation that concurrent menopause hormone remedy enhances the effectiveness of tirzepatide for weight reduction in postmenopausal ladies, researchers carried out a real-world examine utilizing the digital medical information of 120 postmenopausal ladies over a median period of 18 months. The examine included two cohorts: 40 ladies utilizing menopause hormone remedy concurrently with tirzepatide and 80 ladies utilizing tirzepatide alone.
The outcomes confirmed superior whole physique weight reduction share for ladies utilizing tirzepatide plus menopause hormone remedy (17%) in comparison with these utilizing tirzepatide alone (14%). As well as, a better share of menopause hormone remedy customers (45%) additionally achieved at the least 20% whole physique weight reduction, in comparison with 18% of menopause hormone remedy non-users.
“The knowledge garnered via this new examine offers essential insights to develop more practical and personalised weight administration interventions to cut back a postmenopausal lady’s threat of obese and obesity-related well being issues,” mentioned Maria Daniela Hurtado Andrade, M.D., Ph.D., assistant professor of drugs and marketing consultant for the Division of Endocrinology on the Mayo Clinic.
“This examine underscores the pressing want for additional analysis to higher perceive how weight problems drugs and menopause hormone remedy work collectively. Gaining this data might vastly enhance the well being and well-being of tens of millions of postmenopausal ladies. It additionally factors to the necessity for higher methods to make these therapies extra accessible and accessible to those that want them.”
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Mixture of weight problems remedy tirzepatide and menopause hormone remedy fuels weight reduction (2025, July 12)
retrieved 12 July 2025
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