June 06, 2025
1 min watch
Key takeaways:
- Lens thickness elevated with accommodative demand throughout all age teams by a median of 0.013 mm/D.
- In contrast with emmetropes, myopes had considerably shorter lodging response time.
SALT LAKE CITY — The thickness of the crystalline lens might be a marker for accommodative effort in presbyopic eyes, in line with information offered on the Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly.
“We’ve discovered lens thickness to be a really systematic parameter in numerous methods,” Susana Marcos, PhD, instructed Healio. “Lens thickness could be a good marker for accommodative effort and one thing to take a look at maybe as a marker to set off some accommodating system.”
The discovering was enabled by a customized OCT system developed within the lab of Marcos, director of the Heart for Visible Science on the College of Rochester.
“In my lab, we’ve developed plenty of OCTs that work underneath spectral area or swept supply. … [Their] excessive acquisition charges permit us to trace the dynamic nature of the crystalline lens because it accommodates,” Marcos mentioned. “We have now coupled the OCT know-how with highly effective quantification instruments that permit us to appropriate distortions that happen naturally with OCT in addition to to go from the photographs to numbers that describe the crystalline lens in three dimensions.”
Marcos and colleagues used the system to check how accommodative demand in presbyopic eyes impacted the form of the anterior section and crystalline lens.
“Within the final 100 years, scientists have been finding out the lodging response and … why presbyopia happens as a pure ageing of the crystalline lens,” Percy Lazon, PhD, director of analysis applications at CooperVision, which funded the research, instructed Healio. “Dr. Marcos’ instrument pushed the bounds on with the ability to picture the crystalline lens in vivo and in addition observe adjustments that occur throughout lodging and disaccommodation.”
A Badal optometer was used to set off accommodative demand. Each two- and three-dimensional photos have been taken at high-speed acquisition, from which customized algorithms allowed for “geometrical quantification” of anterior chamber depth, lens thickness, pupil diameter and different parameters.
Based on the outcomes, lens thickness was the parameter that underwent probably the most systematic change in response to accommodative demand throughout all age teams. Lens thickness elevated in all eyes besides two by a median of 0.013 mm per diopter of accommodative demand.
The researchers additionally examined variations between presbyopic sufferers with myopia vs. emmetropia. Sufferers with myopia demonstrated bigger adjustments in anterior chamber depth and lens thickness, in addition to a considerably shorter lodging response time, than these with emmetropia.
The findings may ultimately inform new methods within the remedy of presbyopia, the researchers wrote.
“That is one thing very futuristic at this level … however you would envision a extremely tiny OCT system … that can probably monitor lens thickness as a biomarker from an OCT method,” Marcos mentioned.
Additionally, as a result of the crystalline lens is behind the cornea and never readily accessible, the OCT and quantification strategies utilized in Marcos’ lab open “a breadth of prospects,” she mentioned.
“We all know that as myopia develops, the crystalline lens remodels in a sure method, so I believe by making use of these instruments we will have higher insights in how myopia develops and what’s the function of the crystalline lens,” Marcos mentioned.
Reference:
- Marcos S, et al. OCT-based marker of accommodative effort in presbyopes. Offered at: Affiliation for Analysis in Imaginative and prescient and Ophthalmology assembly; Might 4-8, 2025; Salt Lake Metropolis.
For extra info:
Percy Lazon, PhD, could be reached at plazon@coopervision.com.
Susana Marcos, PhD, could be reached at smarcos2@ur.rochester.edu or on X: @MarcosLabUR.
Sources/Disclosures
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Healio Interviews
Disclosures:
Marcos studies having monetary disclosures for 2EyesVision, Adaptilens, Alcon, Azalea Imaginative and prescient, Bausch + Lomb, Clerio Imaginative and prescient, CooperVision, Essilor, Hoya, Johnson & Johnson, PhysIOL/BVI, PlenOptika, Stuart Therapeutics and TearOptix. Lazon studies being employed by CooperVision.
