Key takeaways:
- Sufferers with extreme glaucoma had been extra more likely to expertise steroid-induced ocular hypertension.
- Steroid response was additionally increased in these with earlier glaucoma surgical procedures or on extra preop drugs.
KIAWAH ISLAND, S.C. — Sufferers with worse glaucoma severity had been extra more likely to expertise steroid-induced ocular hypertension, in line with a research introduced at Kiawah Eye 2025.
R. Bryce Robbins, MD, stated spikes in IOP are necessary to think about in sufferers who lately underwent a minimally invasive glaucoma process.
“Some early research steered that roughly one out of eight sufferers have a steroid response in some MIGS [procedures],” he stated. “Extra research are wanted to find out each the medical and demographic predictors of steroid response, significantly in our glaucoma affected person inhabitants.”
Robbins and colleagues performed a retrospective chart evaluate of 143 eyes from 101 sufferers who underwent angle-based MIGS.
Thirty-three sufferers had been categorized at steroid responders and skilled a rise in IOP of at the very least 5 mm Hg from baseline throughout steroid use with out one other trigger that resolved after tapering.
Within the steroid responder group, 45.5% of sufferers had extreme glaucoma (P = .01). Sufferers with the next variety of prior glaucoma surgical procedures or who had been on extra preoperative glaucoma remedy courses had the next probability of being within the steroid responder group (P = .03 and P = .008, respectively).
Sufferers with decrease visible area imply deviation scores and decrease common retinal nerve fiber layer thickness had been additionally extra more likely to be within the steroid responder group (P = .003 and P = .006, respectively).
There was no distinction in steroid response between totally different MIGS procedures, in line with Robbins.
“We did not see a distinction within the charges of secondary surgical interventions between steroid responders and non-responders,” he stated.
Sources/Disclosures
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Robbins RB, et al. Predictors of steroid-induced ocular hypertension. Offered at: Kiawah Eye; Could 29-31, 2025; Kiawah Island, South Carolina.
Disclosures:
Robbins stories no related monetary disclosures.
