In February 2024, the U.S. Division of Well being and Human Companies Panel for the Use of Antiretroviral Brokers in Adults and Adolescents with HIV (ARV Pointers Panel), in collaboration with the American Faculty of Cardiology (ACC), the American Coronary heart Affiliation (AHA), and the HIV Medication Affiliation (HIVMA), developed statin remedy suggestions for individuals with HIV (PWH).
These suggestions had been knowledgeable by the outcomes of the REPRIEVE (Randomized Trial to Stop Vascular Occasions in HIV) examine. A abstract of the suggestions related to physicians is revealed in Annals of Inside Medication.
PWH are extra in danger for a lot of aging-related ailments, together with atherosclerotic heart problems (ASCVD). The REPRIEVE examine was a Part III, world, randomized managed trial of oral pitavastatin versus placebo for the prevention of ASCVD in PWH aged 40 to 75 years at low to intermediate threat primarily based on 10-year threat estimates.
In contrast with placebo, pitavastatin was related to a 36% discount in MACE. These findings knowledgeable the ARV panel to suggest moderate-intensity statin remedy as the first prevention amongst PWH aged 40 to 75 years with low to intermediate 10-year ASCVD threat.
The panel additionally strongly recommends initiating statin remedy amongst individuals with a 10-year ASCVD threat rating of 5% or greater.
For PWH with a 10-year ASCVD threat rating beneath 5%, the panel favored statin remedy but in addition beneficial that affected person–clinician threat discussions take into account HIV-related elements than can improve ASCVD threat.
Amongst PWH youthful than 40 years, choices to provoke statin remedy needs to be individualized and primarily based on threat elements and familial well being historical past. The panel recommends the usage of at the least moderate-intensity statins, together with pitavastatin, 4 mg day by day; atorvastatin, 20 mg day by day; or rosuvastatin, 10 mg day by day.
The authors word that future analysis is required to raised perceive absolutely the threat for ASCVD and different nonischemic CVD manifestations in individuals with HIV.
Extra data:
Statin Remedy as Main Prevention for Individuals with HIV: Suggestions from the U.S. HHS Antiretroviral Therapy Pointers Panel, Annals of Inside Medication (2025). DOI: 10.7326/ANNALS-24-03564
Quotation:
Panel recommends statins for adults with HIV in danger for heart problems (2025, Might 26)
retrieved 26 Might 2025
from https://medicalxpress.com/information/2025-05-panel-statins-adults-hiv-cardiovascular.html
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