Analysis being offered on the European Congress on Weight problems (ECO 2025) and revealed within the journal Vitamins signifies that collagen might be a secure and efficient weight-loss complement.
People with chubby and weight problems who ate protein bars enriched with collagen, a protein that’s present in connective tissue, misplaced twice as a lot weight as a management group who didn’t have the complement. In addition they skilled larger decreases in blood stress and waist circumference and noticed their liver well being enhance extra. They could even have elevated skeletal muscle and fat-free mass.
“Many weight-loss medicine are very costly,” explains researcher Dr. Paola Mogna-Peláez, of the College of Navarra, Pamplona, Spain. “We had been fascinated about collagen as a result of it’s a protein that’s low cost and simple to acquire and isn’t identified to have any side-effects. It’s also a compound that the general public is conversant in.
“Crucially, collagen’s construction could be modified to permit it to soak up additional water, which results in it rising in measurement.
“We wished to know if such a compound creates a sense of fullness when it expands within the abdomen, lowering urge for food and resulting in weight reduction.”
To study extra, Dr. Mogna-Peláez and colleagues performed a 12-week randomized managed trial involving 64 people aged 20–65 years with chubby or weight problems (50% feminine, common weight 83.9 kg/13st 3lb, common BMI 29.65 kg/m2).
All the contributors got wholesome consuming recommendation primarily based on the Mediterranean food regimen. As well as, half of them had been requested to eat a chocolate-flavored protein bar enriched with collagen (10g of collagen per bar) with a glass of water earlier than lunch and dinner every day.
The collagen, which got here from cows, had been handled to soak up additional water, in order that it will enhance in measurement when consumed with water.
The contributors stuffed in an urge for food questionnaire and underwent a spread of physique measurements and different exams at baseline and periodically thereafter.
At 12 weeks, the collagen group had misplaced extra weight than the management group (3 kg/6.6 lb vs. 1.5 kg/3.3 lb). This was regardless of each teams consuming the identical variety of energy, say the researchers.
Systolic blood stress fell by 8 mm Hg within the collagen group however rose barely (0.4 mm Hg enhance) within the management group.
Waist circumference (2.8 cm vs. 2.5 cm), BMI (1.2 models vs. 0.78 models) and fatty liver index, a measure of liver well being, additionally fell extra within the collagen group than within the management group.
As well as, fat-free mass (non-fat tissue together with muscle) elevated within the collagen group, suggesting they might have constructed muscle, however remained unchanged within the management group.
The sarcopenic index, one other measure of muscle mass, elevated in each teams.
Taken collectively, these outcomes point out that the load loss within the collagen group was not attributable to lack of muscle, say the researchers, a few of whom are employed by the agency that makes the complement and the protein bars.
The questionnaire confirmed that the collagen group felt much less hungry and extra full than the management group. Ranges of leptin, a hormone that induces emotions of satiety, fell in each teams however had been greater on the finish of the examine within the collagen group than within the management group.
In animal experiments, collagen decreased ranges of ghrelin, a hormone that simulates urge for food. The complement additionally swelled to nearly 20 instances its authentic measurement in abdomen acid and had low digestibility.
Not one of the contributors reported any side-effects and people within the collagen group rated the bars superb (8.8 out of 10) for style in a questionnaire – one thing the researchers say can seemingly be attributed to the bars being coated with sweetened darkish chocolate.
Dr. Mogna-Peláez says, “Our outcomes point out that, by swelling within the abdomen, the collagen made the contributors really feel much less hungry, which might have led to them consuming much less and so shedding pounds.
“Collagen might also have led to the contributors constructing muscle and we all know that muscle burns extra energy than fats.
“It’s also attainable that collagen modifications the make-up of micro organism within the intestine, which can assist with weight reduction and urge for food management.”
The collagen-enriched protein bars are already in the marketplace. The researchers at the moment are operating a bigger trial to study extra about mechanisms of motion, significantly in relation to the intestine microbiota.
Extra data:
Miguel López-Yoldi et al, Anti-Weight problems Results of a Collagen with Low Digestibility and Excessive Swelling Capability: A Human Randomized Management Trial, Vitamins (2024). DOI: 10.3390/nu16203550
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European Affiliation for the Research of Weight problems
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